We identified 6 novel TNNT2 mutations in DCM patients, including a G12026T (c.252 G>T) missense mutation (Leu84Phe), 5 novel mutations in introns, and 2 novel single-nucleotide polymorphisms (SNP) (c.192 + 353 C>A, c.192 + 463 G>A). This evidence concerns the gene TNNT2 and familial dilated cardiomyopathy.