Therefore, chemoattractant GPCRs are believed to play a crucial role in tumor progression via signaling based on dissociation of trimeric G proteins in response to ligands binding culminating in cell chemotaxis, invasion, production of mediators promoting angiogenesis, transactivation of growth factor receptors, such as epidermal growth factor receptor (EGFR), and tumor cell metastasis. Here, EGFR is linked to neoplasm.