For example, in renal cell carcinoma, tumor cells secrete CCL20 to recruit CCR6(+) immature DCs that mostly elicit tolerance, while, in the tumor invasion margin, only CCL19 and CCL21 are detected and they recruit CCR7(+) mature DCs as well as CCR7(+) T cells to form clusters that provide local foci of antitumor immune responses [62]. The gene discussed is CCR6; the disease is renal cell carcinoma.