Genetic alterations were correlated to adiponectin expression in metabolic diseases [76]; for example, p.G48R, P.Y111H, p.R112C, and p.G90S mutations are strongly associated with low levels of total adiponectin and HMW oligomers in patients affected by T2DM and obesity [43, 45, 46, 77]. The gene discussed is ADIPOQ; the disease is obesity due to melanocortin 4 receptor deficiency.