OLR1 and diabetes mellitus: The LOX-1 promoter is constitutively active only at low levels but may rise in different pathological conditions, including hypertension, hyperlipidemia, diabetes, and atherosclerosis [22], and its expression can be induced by different ligands or activators, including oxLDL, shear stress, phorbol 12-myristate 13-acetate (PMA), advanced glycation end products (AGEs), and others [32, 56, 57].