Animal models echoed these findings; for example, increased expression of IL-17 in mice transfected with fibrosarcoma cells was associated with tumours exhibiting higher MVD through upregulation of VEGF, keratinocyte-derived chemokine (KC or CXCL1 and CXCL 2), macrophage inflammatory protein-2 (MIP-2), prostaglandins PGE1 and PGE2, and nitric oxide (NO) production by fibroblasts and stromal cells [66]. This evidence concerns the gene IL17A and neoplasm.