This transcription factor is well characterized to produce numerous proinflammatory cytokines including IL-6 and IL-8 [103]; an IL-6-mediated promotion of angiogenesis by IL-17 is noted in another in vivo study looking at human melanoma [33] and IL-8 is known to be a potent stimulator of angiogenesis and tumour growth [78]. Here, CXCL8 is linked to melanoma.