Upon treatment with anti-VEGF antibodies the subject tumours recruited higher numbers of CD4+ CD8+ T-cells (although CD4+ numbers were 10 times higher than CD8+); specifically the IL-17+-IL-22+-CD4+ (mature Th17) lymphocytic infiltration was associated with higher CD11b+Gr1+ cells and amplified expression of both G-CSF and IL-17. This evidence concerns the gene CD8A and neoplasm.