Similarly, having established a strong connection between multiple myeloma and IL-17, patients suffering from multiple myeloma also display a significant rise in IL-17 levels both in the serum and in bone marrow biopsies [44, 122, 123], with myeloma marrow infiltrating lymphocytes (displaying the IL-17 phenotype) being a strong predictor of lytic bone disease, an effect of the activation of osteoclasts by IL-17 [124]. Here, IL17A is linked to plasma cell myeloma.