Two other polymorphisms seem to be connected with an increased risk of breast and endometrial cancer: the polymorphism at position 10,398 (G-to-A) of the ND3 gene, associated with the mitochondrial haplogroup N, changes the codon A114T, and is reported to associate with an increased incidence of breast cancer (14,27). Here, MT-ND3 is linked to breast carcinoma.