Two other polymorphisms seem to be connected with an increased risk of breast and endometrial cancer: the polymorphism at position 10,398 (G-to-A) of the ND3 gene, associated with the mitochondrial haplogroup N, changes the codon A114T, and is reported to associate with an increased incidence of breast cancer (14,27). The gene discussed is MT-ND3; the disease is endometrial cancer.