Five DEGs were identified in the Homo sapiens (hsa)04350:TGF-beta signaling pathway term, including SMAD9, ACVRL1, TGFBR1, DCN and TGFB1. The autosomal recessive Alport syndrome is a genetic condition characterized by kidney disease, hearing loss and eye abnormalities. Here, ACVRL1 is linked to Alport syndrome.