They suggest that local acute CORT changes in the hippocampus at the time of learning is in part responsible for glucocorticoid-dependent memory impairments, rather than the chronic cumulative effects of elevated plasma CORT levels on hippocampal morphology and function (Landfield et al., 2007, Lupien et al., 1998, Sapolsky, 1996). Here, CORT is linked to memory impairment.