Whereas most of the APP FAD mutations lead to early-onset familial AD with variable CAA, the APP E693Q (E22Q of Aβ) mutation is known to cause hereditary cerebral hemorrhage with amyloidosis of Dutch type (HCHWA-D, herein referred to as Dutch) with affected brains exhibiting extensive CAA but limited parenchymal Aβ deposits[15]. This evidence concerns the gene APP and amyloidosis.