APP and amyloidosis: These results, on one hand are consistent with our observations that CBF changes in both directions can aggravated amyloid pathology, but on the other hand are different from our observations in that we did not observe amyloid deposit in wild type mice (C57Bl/6 J), nor can we detect amyloid deposits in our APP-DSL knock-in mice of the same young age group (3-month of age) 12 weeks post TAC surgery (data not shown).