Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene (PARK8, OMIM 609007) are associated to late-onset, autosomal dominant Parkinson's disease (PD), and account for up to 13% of familial and 1–2% of sporadic PD cases (Paisan-Ruiz et al., 2004, Zimprich et al., 2004). This evidence concerns the gene LRRK2 and Parkinson disease.