The affected 5q LOH interval harbors several cytokine genes (including IL-3, IL-4, IL-5, IL-13, and CSF2), a gene associated with arthritis susceptibility (SLC22A4), a DNA repair gene (RAD50), and a gene that promotes Type 1 interferon responses (IRF1) [45–50]. The gene discussed is RAD50; the disease is arthritic joint disease.