At TBM diagnosis, blood concentrations were similar between TBM-IRIS and TBM-non-IRIS with the exception of IFN-α2 (P = .03), CXCL8 (P = .005), and MMP-1 (P = .04) concentrations, which were higher in patients with TBM-IRIS (Supplementary Figure 1 and Supplementary Table 3). Here, MMP1 is linked to meningeal tuberculosis.