Moreover, comparing findings between samples taken 2 weeks after starting ART to those from TBM diagnosis in TBM-non-IRIS, a significant decrease was noted in CSF concentrations of G-CSF, GM-CSF, CCL3, CCL4, TNF, IFN-γ, IL-6, CXCL8, CXCL10, lipocalin 2, S100A8/A9, MMP-10, and TIMP-1. This evidence concerns the gene TIMP1 and meningeal tuberculosis.