Conversely, concentrations of only 6 of 25 mediators in blood differed between groups; IFN-γ, IL-6, CXCL8, CXCL10, and MMP-3 concentrations were higher (P < .05), and CCL2 concentrations were lower (P = .045) in patients with TBM. This evidence concerns the gene IFNG and meningeal tuberculosis.