The pathological manifestations of Lowe syndrome and Dent's disease are thought to arise from abnormal protein sorting and membrane recycling (Erdmann et al., 2007; Swan et al., 2010; Vicinanza et al., 2011; Mehta et al., 2014), as loss of OCRL would disrupt the appropriate coordination between membrane progression and changes in phosphoinositide composition. Here, OCRL is linked to oculocerebrorenal syndrome.