In addition, these two EIAV strains acted similarly on ELR1 expression but induced TLR3 expression differently, which implicates that ELR1 does not play an essential role in the resistance to subsequent infection inducted by EIAVFDDV13. In contrast to intact membrane-bound ELR1, a 2- to 3-fold difference in the expression of sELR1, the soluble form of ELR1, was detected after infection of eMDM with EIAVFDDV13, but not EIAVUK3. Here, TLR3 is linked to infection.