TRPM8 channels endogenously expressed in the prostate cancer cell line LNCaP display strongly divergent biophysical properties compared to TRPM8 channels in DRG cells (e.g. they have an inward rectifying I/V relationship) but also appear to be permeable to Ca2+, Sr2+, Ba2+ and Mn2+ [202]. The gene discussed is TRPM8; the disease is prostate cancer.