Based on iTRAQ proteomics analysis, western blot and immune staining, we confirmed that the expression of Cyclin E, SKP2, Stathmin in HEY PGCCs with budding daughter cells were higher than those in control HEY cells, which may provided new insight into how PGCCs and regular cancer cells are coordinately regulated in the progression of human ovarian carcinomas. Here, SKP2 is linked to ovarian carcinoma.