MAPK3 and familial pancreatic carcinoma: Extracellular signal-regulated protein kinases 1 and 2 (ERK1/2) are members ofthe mitogen-activated protein kinase super family that can mediate cellproliferation and apoptosis [19].Furthermore, RNAi-mediated down-regulation of ERK1/2 expression can lead to potentantitumor activity and chemosensitizing effects in human pancreatic cancer and OS[15, 19].