TP53 and glioblastoma: On the other hand, for the two detected low-frequency mutated genes TAF1 (2/170) and SYNE1 (3/170), TAF1 encoding a transcription initiation factor phosphorylates TP53 during G1 cell-cycle progression, so TAF1 may be a member of the p53 signaling pathway; SYNE1 was found to be associated with the GBM patients’ lifetime, and was therefore considered to be an important biomarker of glioblastoma survival [45].