Inhepatocellular carcinoma (HCC), miR-145 was found to target a number of genes alongthe signaling pathway of insulin-like growth factor (IGF), including IGF-1 receptor,insulin receptor substrate-1 (IRS-1), and IRS-2, all of which are directlydownregulated by miR-145 [8]. Here, IRS1 is linked to hepatocellular carcinoma.