This DSS colitis switches from a Th1-Th17-mediated acute inflammation with increased levels of TNF-α, IL-6 and IL-17, to a predominant Th2-mediated inflammatory response that shows a decrease in TNF-α, IL-6 and IL-17 while increasing levels of anti-inflammatory cytokines IL-4 and IL-10 [24]. Here, IL17A is linked to colitis.