Moreover, we here also showed that not only delivery of the pValac:il-10 plasmid by the invasive strain L. lactis MG1363 FnBPA+, but also by the non-invasive L. lactis MG1363 strain, was effective at diminishing intestinal inflammation, showing that this strategy presents potential for therapeutic intervention of IBD. The gene discussed is IL10; the disease is inflammatory bowel disease.