In B-cell lymphoma cell lines derived from Kaposi’s sarcoma herpes virus-associated malignancies like primary effusion lymphoma (PEL) including EBV-negative cell lines Bcbl-1 and BC-3, and EBV-positive JSC-1 cells (latency type II), Fascin was only detectable at low amounts in the PEL-cell line JSC-1. Here, FSCN1 is linked to primary effusion lymphoma.