Both LMP1-mediated transcriptional, posttranscriptional and posttranslational regulation of cellular targets could contribute to the capacity of LMP1 to promote spreading of tumor cells: (1) LMP1 causes loss of junctional plakoglobin in nasopharyngeal carcinoma (NPC) cells and initiates a cadherin switch [[52]]. This evidence concerns the gene JUP and neoplasm.