Evidence suggests that visuo-motor deficits may be one of the most characteristic features of WS [41], and the IPS results in our 8 atypical cases (with 3 different patterns of atypical deletions) point to GTF2I and/or GTF2IRD1 as critical for the performance of these tasks, as suggested previously [15], [38]. This evidence concerns the gene GTF2I and Werner syndrome.