In addition to the possible effect of DISC1 genotype variation on brain function and structure in the hippocampus [16] and cingulate cortex [17] in healthy subjects, our preliminary magnetic resonance imaging (MRI) study suggested that it might differentially affect GM volume of the neocortical and limbic regions in schizophrenia patients and healthy controls [18]. The gene discussed is DISC1; the disease is schizophrenia.