TP53 and breast carcinoma: Studies showed that fifty one variants in 40 genes are significantly associated with breast cancer risk and among them variants in six genes i.e., BRCA1, BRCA2, TP53, PTEN, STK11 and CDH1 show strong association whereas variants in four genes i.e., ATM, CHEK2, BRIP1, PALB2 show moderate association and approximately 20 variants in other genes show weak association [3], [4].