INS and type 2 diabetes mellitus: The T/T genotype of the rs225017 polymorphism remained significantly associated with HOMA-IR [standardized coefficient B for T/T genotype  = −0.366, 95% CI (−0.654–−0.078); P = 0.013] and insulin levels [standardized coefficient B for T/T genotype  = −0.268, 95% CI (−0.441–−0.096); P = 0.002], after adjusting for age, sex, BMI and use of medication for T2DM (mainly metformin or sulfonylureas).