MYOM2 and infection: Crucial evidence for the central role of M in determination of budding sites was obtained from studies on MeV and NiV, where experiments showed that while the glycoproteins are intrinsically targeted to the basal side of polarized membranes, budding of virus particles occurs at the apical side where the M protein is concentrated, and expression of M during infection partially redirects the glycoproteins to apical surface [150,186,187,195,196,197].