Cell proliferation assays revealed that the growth rates were significantly inhibited in both SW480 and DLD-1 cancer cells after SIRT3 siRNA transfection (SW480: 0.75 ± 0.09 versus 0.32 ± 0.11; DLD-1 : 0.74 ± 0.13 ± 0.06; both: P < 0.001, Figure 4(a)). This evidence concerns the gene SIRT3 and cancer.