REN and diabetic retinopathy: The role of the RAS in diabetic retinopathy has not been as well studied as that in the kidney and nephropathy; however, several studies including the Renin-Angiotensin System Study (RASS), Daily-Dose Consensus Interferon and Ribavirin: Efficacy of Combined Therapy (DIRECT) trial, and the ADVANCE Retinal Measurements (AdRem) have provided evidence that RAS inhibition may also be beneficial in diabetic retinopathy [140, 141].