Moreover, nearly 40% of patients with high tumor Sulf1 expression have the hepatoblast phenotype of HCC, which has relatively poor survival (108) and those with mid Sulf1 expression had a better survival outcome possibly due to the complex interaction of Sulf1 with anti- and pro-tumorigenic signaling molecules, indicating a bimodal effect in HCC (107). Here, SULF1 is linked to hepatocellular carcinoma.