Moreover, it is well known that both conditions are associated with insulin resistance, an increased plasmatic level of free fatty acids, of pro-inflammatory cytokines such as tumor necrosis factor alfa (TNF-α), interleukin 6 (IL-6) and decreased levels of adiponectin which is considered to be a protective cytokine [65, 82, 83]. The gene discussed is ADIPOQ; the disease is Insulin resistance.