According to the metal specificity of the complexes formed the latest ones demonstrated reciprocal or similar effects on the cytokine production by responsive cells, and in a comparison with the action of control γ-globulins were found to induce or inhibit production of IFN-γ, IL-1β, IL-2, and IL-6 by normal human PBC [33–35], to similarly enhance production of TNF-α, IL-18, and IL-10 [36–38], or to have no effects with reference to IL-4 or IL-17 [38]. Here, IL1B is linked to primary biliary cholangitis.