CAV1 and colorectal carcinoma: Previously, CAV1 has been reported to be downregulated in CRC and possessed “differential biphasic expression” which supports the findings that CAV1 is positively correlated with miR-133a in CRC patients, particularly in those who developed distant metastases, since advanced tumor progression and metastasis were associated with higher miR-133a expression as demonstrated in this study [17, 18, 24].