Despite the fact that patients had already undergone the sufficient treatment of their heart failure (HF), the combined proportion of patients with NYHA class III and IV HF was as high as 43.2 %, mean LVEF was 37.9 %, mean CTR was 56.7 %, and median plasma BNP concentration was 312.8 pg/mL. The gene discussed is NPPB; the disease is heart failure.