The proportions of patients were 40.9 % (47/115) to 73.9 % (85/115), who were analyzed for seven investigation items: vital signs [body weight, pulse rate, systolic blood pressure (SBP), and diastolic blood pressure (DBP)], echocardiography, BNP, renal function test, symptoms of CHF, chest X-ray, and hematology. The gene discussed is NPPB; the disease is congestive heart failure.