They were also more often erosive on radiography, ACPA and RF positive, currently treated with DMARDs (monotherapy with methotrexate or sulfasalazine in 11, combination therapy in five individuals (including anti-tumor necrosis factor alpha therapy in four)), had higher HAQ-scores, GS synovitis and US erosive joint counts, RAMRIS erosion and oedema scores in the wrist and MCP joints, and synovitis scores in MCP joints. Here, TNF is linked to synovitis.