However, a smaller study of MC4R in a Belgian case/control study (1,049 obese/312 control) reported that a promoter SNP rs11872992 was associated with obesity (p = 0.03, Table 1), and this signal was independent from rs17782313 (Beckers et al. 2011). Here, MC4R is linked to obesity due to melanocortin 4 receptor deficiency.