(7) Unusual patients with “euthyroid Graves’ disease”, whose TFTs are consistently within the normal ranges could arguably be considered euthyroid set points due to an equimolar mixture of TSH receptor stimulating and blocking autoantibodies with a ‘tug-of-war’ stoichiometric ratio resulting in euthyroidism; subsequent development of thyrotoxicosis or hypothyroidism due to antibodies imbalance allows HP curves to be plotted for set point computations. The gene discussed is TSHR; the disease is hypothyroidism.