From stage 1 meta-analysis, 49 SNPs moderately associated with T2D (P<1×10−5) and two candidate SNPs near the p value threshold (rs231356 at KCNQ1, P = 2.84×10−5 and rs2244020 at HLA-B, P = 1.02×10−5) totaling 51 SNPs in 21 loci were followed up for replication. This evidence concerns the gene KCNQ1 and type 2 diabetes mellitus.