GLIS3 and type 1 diabetes mellitus: On the other hand, evidence has implicated T1D loci HLA-DQ/DR, GLIS3 and INS in the susceptibility of latent autoimmune diabetes in adults (LADA) and/or T2D [7], [34], [45]–[46], while T2D loci such as PPARG and TCF7L2 was associated with T1D [47] and LADA [46], [48], respectively.