Using the Systemic intravenous injection model, we observed that the antitumor activity of Rv0652 originates from a marked increase in IFN-gamma production by the T cells in draining LNs that are primed by DCs stimulated with Rv0652, an increase in the number of functional Ag-specific CTLs, and increased tumor infiltration of CD8+CD69+ T cells. Here, CD8A is linked to neoplasm.