Indeed, if we make all cells transit every LN in the “optimal” 11.7 h instead of transiting randomly in our previous simulation (infection in 25% of the LN spheres, 8 h phase I, signal integration), the capture time slightly decreases from ∼5.5d to ∼4d – in other words, precisely timed LN transit can lead to 1.4-fold faster Ag detection in this setting. The gene discussed is RENBP; the disease is infection.