The affinity results showed that the E117Q mutation obviously strengthened the binding between CMG2 and PA, and the neutralization assays in vitro and in vivo confirmed that CMG2-Fc (E117Q) could neutralize anthrax toxin and protect F344 rats against lethal toxin challenge; these assays also indicated that CMG2-Fc (E117Q) is preferable to CMG2-Fc and can be used to treat anthrax infection together with other anti-anthrax molecules. Here, ANTXR2 is linked to anthrax infection.