GUCY2C and neoplasm: For example, the ability of CDX2/AS to regulate the splicing of GUCY2C could impact numerous processes since GUCY2C is an intestinal tumor suppressor, which regulates key homeostatic functions including proliferation and the cell cycle, metabolism, differentiation, DNA damage sensing and repair, epithelial-mesenchymal interactions, and intestinal barrier function [47]–[49].