Induction of a cassette of genes mediating intestinal differentiation, development of increased number of colonic tumors in APC+/delta716CDX2+/− compound mutant mice, and loss of CDX2 expression in a subset of minimally differentiated colonic tumors has established CDX2 as a putative intestinal tumor suppressor [30], [31]. The gene discussed is APC; the disease is colonic neoplasm.