The current meta-analysis implied a conspicuously significant relationship between TNF-α-308A/G gene polymorphism and DM risk under the allele model (A allele vs. G allele, P<0.0001), dominant genetic model (AA+AG vs. GG, P<0.0001) and additive model (AA vs. GG, P<0.0001). This evidence concerns the gene TNF and dermatomyositis.