DES and cardiomyopathy: In a model of desmin-related cardiomyopathy produced by the cardiomyocyte-specific transgene expression of mutant αB-crystallin (CryABR120G), aggregates were observed within cardiomyocytes leading to altered cardiomyocyte functions, perturbations in mitochondrial-sarcomere architecture, and deficits in mitochondrial function, which resulted in apoptosis and heart failure [19].