The magnitude of these physiological changes was accompanied in both HD models by reactivation of a foetal gene programme, including the up-regulation of Anp, Bnp, Fhl1 and Fhl2 and a reduction in the α- and β- isoforms of the myosin heavy chain, all typical markers of an induced cardiomyopathy. The gene discussed is NPPA; the disease is cardiomyopathy.