Perillyl alcohol inhibited the proliferation of human non-small cell lung cancer cells (A549 and H520) with IC50 values greater than 1 mM, inducing cell cycle arrest and apoptosis with increases in the expression of Bcl2, bax and p21 and in the caspase-3 activity [37]. The gene discussed is BCL2; the disease is non-small cell lung carcinoma.