BCL2 and colorectal cancer: Zhang et al. found that miR-148a significantly induced cell apoptosis by directly targeting Bcl-2 in RKO and Levo colorectal cancer cell lines [31], while Cimmino et al. showed that when miR-15 and miR-16 were reexpressed cell apoptosis was significantly upregulated in MEG-01 leukemia cells by directly targeting Bcl-2 [32].