BRAF and melanoma: Given the almost universal dependence of melanomas from hyper-activation of the MAPK signalling pathway caused by activating mutation of NRAS, BRAF or loss of function mutations of the RAS-negative regulator NF1, it is of particular interest the work reported by Basu and colleagues [138], which generated and tested nanoparticles loaded with the MEK1 inhibitor PD98059 and proved its ability in enhancing the antitumor activity to cysplatinum.