CD8A and melanoma: Speiser et al. prepared a nanoparticle containing a cytosine-phosphodiester-guanine- (CpG-) loaded virus-like particle carrying melanoma antigen recognized by T cells 1 (Mart-1) to target melanoma cells, and this nanoparticle produced a strong immune response against melanoma, including increased cytotoxic CD8 T cell responses [152].