TBX5 and malignant colon neoplasm: In fact, novel cancer-related genes that are epigenetically silenced have been described and, thereafter, defined as important molecular actors in the development of malignant diseases, especially the T-box transcription factor 5 (TBX5) gene in colon cancer [25] and the pituitary tumor apoptosis gene (PTAG) in pituitary adenomas [26].