Currently, the multikinase inhibitor sorafenib is still the only approved drug for patients with advanced HCC and it has been demonstrated that the mechanisms that account for the antiangiogenic efficiency of sorafenib is associated with its inhibitory effect on the expression of HIF-1 and VEGF proteins, leading to a decrease in vascularization of HCC [57]. Here, VEGFA is linked to hepatocellular carcinoma.