MYC and medulloblastoma: It has been proposed that group 3 medulloblastomas are further categorized in to 3α and 3β based on the expression of Myc (5) with 3α tumors have MYC amplification and hence carry a worse prognosis (5) and 3β not over-expressing MYC and have a similar prognosis to group 4 tumors – underlying the fluid nature of these classifications at present (5).