DBP and tuberculosis: We subsequently demonstrated that, in TB patients from various ethnic backgrounds, DBP haplotypes are significantly associated with variation in serum DBP levels; patients of African ancestry who more commonly carry the DBP Gc1F haplotype have low circulating DBP levels, while Eurasians who commonly carry the Gc1S haplotype (D416E amino acid change) have high circulating DBP levels and individuals who are Gc2 or Gc1F-Gc1S have intermediate DBP levels (Figure 2) [33].